- THN391 was found to be safe and well-tolerated -
- THN391 demonstrated a prolonged half-life and dose proportional Cmax levels -
- The data will be presented October 25-27th at CTAD 2023 -

SACRAMENTO, Calif., Oct. 24, 2023 (GLOBE NEWSWIRE) -- Therini Bio, Inc., a biotech company focused on developing fibrin targeted therapies to treat inflammatory neurodegenerative and retinal diseases, today announced interim results from the Phase 1 trial of its lead candidate, THN391, for the treatment of dementia. The data will be detailed in a poster presentation at the 16th Clinical Trials on Alzheimer's Disease (CTAD) conference taking place from October 25-27, 2023, in Boston, MA.

Vascular dysfunction is a key driver in many neurodegenerative diseases, with fibrin playing a major role. Fibrin is a protein that is essential for blood clotting, but factors such as aging, vascular and rheumatological diseases and genetic risks, have shown fibrin to also cause chronic neuroinflammation and innate immune activation, resulting in severe retinal and neurological diseases, including Alzheimer's. THN391 is a potential first-in-class, therapeutic, monoclonal antibody that is designed to target the inflammatory properties of fibrin without disrupting coagulation and protective innate immunity.

The Phase 1 trial evaluating THN391 consists of single ascending dose (SAD) and multiple ascending dose (MAD) portions, which are designed to study the safety and tolerability of THN391 in healthy subjects, as well ...

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